Basic & Clinical Medicine ›› 2018, Vol. 38 ›› Issue (6): 849-852.
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Abstract: Exosomes are membrane vesicles that are secreted by cells into the extracellular environment. Exosomes are a new strategy for the treatment of spinal cord injury. Exosomes are secreted by mesenchymal stem cells have anti-apoptotic, anti-inflammatory and pro-angiogenic effects in the treatment of spinal cord injury, which play a key role in nerve cell-cell communication and can delivery exogenous genetic material. Exosomes can cross the blood-brain barrier and are more stable than their parent cells, reducing the safety risks in the administration of viable cells.
Key words: spinal cord injury, exosomes, MSCs, siRNA
CLC Number:
R34
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