Abstract: Objective To investigate the expression of ACCα and SREBP-1c of selenium-enriched Ganoderma lucidum polysaccharides on fatty liver rats model. Methods 120 SD rats were randomly divided into control, high-fat diet, polyene phosphatidylcholine, Se G. lucidum polysaccharides low, medium and high group, after 4 and 8 weeks of treatment the rats were sacrificed, measuring the AST, ALT, CHOL and TG in blood serum, detect SREBP-1c, ACCα mRNA and protein expression by Western Blot and PCR respectively. Results With the increase of treatment dose and treatment time of Se G. lucidum polysaccharides, fatty infiltration of the liver was significantly reduced, fat particles significantly reduced; liver function and blood lipids significantly improved; SREBP-1c, ACCα mRNA and protein expression was significantly decreased. Conclusion Se G. lucidum polysaccharides can relieve the symptoms of non- alcoholic fatty liver disease in rats.

Key words: Se Ganoderma lucidum polysaccharides, nonalcoholic fatty liver, sterol regulatory binding proteins -1c, acetyl coenzyme A carboxylase α