Abstract: Objective To investigate the effect of BEZ235 on breast cancer cells. Methods Proliferation ability of human triple negative breast cancer cell line MDA-MB-231 and triple positive breast cancer cell line MCF-7 was detected by MTT assay; the xenograft model to analysis the ability of exhibited breast cancer proliferation in vivo; Western blot method to detect the PI3K/Akt signaling pathway related protein level. Results BEZ235 significantly inhibited the proliferation of breast cancer cells (p<0.01). Especially BEZ235 can strongly inhibited the triple negative breast cancer MDA-MB-231 cells in vivo and in vitro (p<0.01). Conclusion BEZ235 may through the inhibition of PI3K/Akt signaling pathway proteins phosphorylation to inhibition of breast cancer cells in vitro and in vivo.

Key words: BEZ235, triple negative breast cancer, protein phosphorylation