Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (2): 207-210.
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1,Fang WANGAi-Hua Liang
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Abstract: Objective To investigate the effects of miR-760 on cell proliferation, migration and invasion of gastric cancer cell line MGC-803. Methods The level of miR-760 expression was detected by real-time RT-PCR in 50 paired gastric cancer tissues and their adjacent normal tissues. miR-760 overexpression was achieved by transfection of construct pcDNA-miR-760 into MGC-803 cells. The proliferation, migration and invasion of MGC-803 cells were detected by the CCK-8, Transwell and scratch wound assay, respectively. Results miR-760 was decreased in 36 cases (72%) of gastric cancer tissues compared to their control. Furthermore, overexpression of miR-760 effectively inhibited the migration and invasion of MGC-803 cells(p<0.05), but had no effects on proliferation. Conclusion Down-regulation of miR-760 has a correlation with the progression of gastric cancer. Up-regulation of miR-760 can inhibit the invasion and migration of MGC-803 cells.
Key words: Key words:miR-760, gastric cancer, proliferation, migration, invasion
CLC Number:
Q527
Fang WANG Ai-Hua Liang. Effects of miR-760 on cell proliferation, migration and invasion of gastric cancer cell lines MGC-803[J]. Basic & Clinical Medicine, 2016, 36(2): 207-210.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2016/V36/I2/207