Abstract: The proto-oncogene FBI-1 is also called ZBTB7, LRF and Pokemon. Its encoding product belongs to the members of the family of POK protein and it has functions of transcriptional suppression. The overexpression of FBI-1 can repress the expression of Rb gene and ARF gene through its special protein structure. And it has played an important role in cancer’s occurrence, development and outcome. In recent years, many medical institutions have done researches about FBI-1gene in prostate cancer. The proto-oncogene FBI-1 might be a new target in cancer prevention, diagnosis, treatment and prognostic evaluation.

Key words: proto-oncogene, FBI-1, prostate neoplasms