Basic & Clinical Medicine ›› 2014, Vol. 34 ›› Issue (11): 1548-1552.
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Abstract: Objective To prepare TF conjugated doxorubicin and embelin loaded liposome and evaluate their properties and effect on the treatment of breast cancer. Methods The liposomes were prepared by thin film hydration method. The efficiency of cellular uptake on MCF-7 cells in vitro was evaluated. The anti-proliferation efficiency of TFLP-DOX/EB was evaluated by MTT assay. Tumor spheroids were used to evaluate anti-tumor ability of TF-LP-DOX/EB. Results The result demonstrated that TFLP uptaken by MCF-7 were 3.2 times higher than that of LP(P<0.01). The MTT assay and the inhibition of tumor spheroids in vitro confirmed strong inhibitory effect of TFLP-DOX/EB. Conclusion TFLP-DOX/EB were easy to prepare and it is a potential delivery system for the treatment of breast cancer.
Key words: transferrin, doxorubicin, embelin, tumor targeting
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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2014/V34/I11/1548