Abstract: Multiple sclerosis is an immune-mediated disorder in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms. Zebrafish is an ideal model for investigating vertebrate demyelination and remyelination, due to the rapid external development and transparency of the embryos. Transgenic zebrafish allows visualization of cells in living zebrafish and provides a rapid, real-time in vivo system for the analysis of gene expression patterns.

Key words: demyelinating diseases, multiple sclerosis, zebrafish, remyelination