Basic & Clinical Medicine ›› 2013, Vol. 33 ›› Issue (4): 500-503.
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Abstract: Aberrant methylation of tumor suppressor genes may cause transcriptio-nal silence.Aberrant methylation of DNA repair genes such as MGMT,hMLH,B-RCA would result in decreased repair protein synthesis,genomic instability,decre-ased repair capacity,increased mutation rate and finally cacinogensis.
Key words: DNA repair genes, methylation, carcinogenesis
CLC Number:
R730.231+.3R730.231+.3
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2013/V33/I4/500