Basic & Clinical Medicine ›› 2012, Vol. 32 ›› Issue (4): 453-456.
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Abstract: Abstract:Abnormal activated T cells infiltration and cytokine production are predominant mediators of skin pathology in psoriasis, a chronic inflammatory skin disease. Psoriasis has been definited as a T helper (Th) 1-type disease mediated by IL-12 、IFN-γ、TNF-α. Recently, Accumulating evidence suggests that IL-23 and the subsequent Th17 cell response it promotes are central factors in the pathogenesis of this disease.IL-23 is a central growth factor for Th17 cells as it influences both their differentiation and expansion.Th17-related cytokines including IL-17、 IL-21、IL-22 play a functional role in psoriasis and other Autoimmune diseases.
Key words: IL-23 , Th17, IL-17, Psoriasis
CLC Number:
R392.32
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http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2012/V32/I4/453