Abstract: Objective To compare MSCs’ immuno-modulatory property between bone-marrow derived and adipose derived MSCs. Methods Phenotype analysis of both MSCs populations was detected by flow-cytometry. To analyse immuno-modulatory effect of MSCs, proliferation, cell cycle, activation, apoptosis and Th1/Th2 balance were analyzed after co-culturing lymphocytes and MSCs.　Results Phenotype analysis showed that AMSCs had the similar expression of markers with BMSCs. Both AMSCs and BMSCs could inhibit T cells proliferation and activation. Also MSCs’ effect on Th cell differentiation into Th1 or Th2 was similar between AMSCs and BMSCs. Nevertheless, BMSCs could suppress activated T cell apoptosis, while AMSCs could not. Conclusion AMSCs and BMSCs showed similar immuno-modulatroy effect on T lymphocytes, however the difference effect on activated T cell apoptosis of the two cell populations was still unclear and the possible mechanism would be studied.

Key words: Bone marrow derived MSCs, Adipose derived MSCs, immuno-modulatory