Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (1): 38-45.doi: 10.16352/j.issn.1001-6325.2023.01.0038

• Invited Reviews: Basic Research and Clinical Translation of Adult Stem Cells • Previous Articles     Next Articles

Research advances in application of mesenchymal stem cells for aging related diseases

SHANG Lipeng1, LIU Guoxiang2, DING Xiaoyan1, LI Bing2, ZHAO Chunhua1,3,4, LI Xiaoxia1,2*   

  1. 1. Institute of Stem Cell and Regenerative Medicine; 2. Department of Genetics and Cell Biology, College of Basic Medicine, Qingdao University, Qingdao 266071;
    3. Center of Excellence in Tissue Engineering, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005;
    4. Department of Cell Biology, School of Life Sciences, Shanghai University, Shanghai 200444, China
  • Received:2022-07-13 Revised:2022-10-10 Published:2022-12-27
  • Contact: *

Abstract: Aging related diseases seriously affect the health of the elderly. Studies on the roles and mechanisms of mesenchymal stem cells (MSCs) in aging related diseases have attracted more and more attention. Besides, a number of relative clinical trials have been carried out in the domestic and overseas. This review summarizes the roles, molecular mechanisms, clinical trials of MSCs and MSCs-derived exosomes in several typical age-related diseases such as osteoporosis, Alzheimer's disease, Parkinson's disease, type 2 diabetes, atherosclerosis, chronic obstruc-tive pulmonary disease and tumor. This review may provide some theoretical reference and advices for future studies of MSCs in aging related diseases.

Key words: mesenchymal stem cells(MSCs), aging related diseases, exosome

CLC Number: