Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (1): 174-177.doi: 10.16352/j.issn.1001-6325.2023.01.0174

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Ferroptosis in the treatment of colorectal cancer

ZHUANG Zhicheng, GUAN Guoxian*   

  1. Department of Colorectal Surgery,the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
  • Received:2021-09-07 Revised:2021-12-31 Published:2022-12-27
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Abstract: Ferroptosis is a form of programmed cell death caused by accumulation of iron-dependent lipophilic reactive oxygen species. Its occurrence depends on the comprehensive changes of intracellular iron homeostasis, lipid metabolism and antioxidant system. Colorectal cancer is one of the common malignant tumors of the digestive tract. It can effectively inhibit the proliferation of colorectal cancer cells, reverse drug resistance and improve the radio sensitivity of colorectal cancer cells by inducing ferroptosis pathway.

Key words: colorectal cancer, ferroptosis, cancer treatment, radiation therapy, chemotherapy

CLC Number: