Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (8): 1274-1278.doi: 10.16352/j.issn.1001-6325.2022.08.1274

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Research progress of RNA binding motif protein family-mediated alternative splicing in cardiomyopathy

LIU Shu1,2, DING Hong1, ZHAO Ke-xin1,2, BAI Feng1, ZHANG Xiao-wei1*   

  1. 1. Department of Cardiology, the Second Hospital of Lanzhou University; 2. the Second Clinical Medical College of Lanzhou University, Lanzhou 730030, China
  • Received:2021-03-18 Revised:2021-08-24 Online:2022-08-05 Published:2022-08-02
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Abstract: RNA binding motif protein (RBM) is a type of RNA binding protein, which contains RNA recognition motif, RNA binding motif and ribo-nucleo-protein motif. The alternative splicing mediated by members of the RBM family is closely related to myocardial contractile proteins, myocardial development and myocardial sodium channels, which play an important role in pathogenesis of myocardial diseases and even heart failure.

Key words: RNA binding motif protein, alternative splicing, cardiomyopathy

CLC Number: