Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (4): 628-632.doi: 10.16352/j.issn.1001-6325.2022.04.020

• Original Articles • Previous Articles     Next Articles

Changes of BMP-2 and BMP-4 in early phase of sepsis

WEN Yan1, LIN Jin-can2, HUANG Ying-hong1, XIAO Wen-biao1, ZHANG Min-wei2, LIN Jian-dong1*   

  1. 1. Department of Intensive Care Unit, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005;
    2. Department of Intensive Care Unit, the First Affiliated Hospital of Xiamen University, Xiamen 361003, China
  • Received:2021-06-28 Revised:2021-12-13 Online:2022-04-05 Published:2022-04-01
  • Contact: *

Abstract: Objective To study the change of serum bone morphogenetic protein (BMP)-2 and BMP-4 during the development of sepsis and its mechanisms. Methods Blood was collected for quantifying serum BMP-2 and BMP-4 from patients with sepsis (sepsis group), patients without sepsis (non-sepsis group) in 24 hours of ICU admission and from healthy volunteers (control group). Concentration of serum BMP-2 and BMP-4 was determined by ELISA. The expression of BMP-2, pSmad1/5, and BMPRⅡ of lip polysaccharide (LPS)-treated rat pulmonary microvascular endothelial cells (RPMECs) was detected by Western blot. Results Serum BMP-2 and BMP-4 were significantly increased in sepsis group (P<0.05) and the level of BMP-2 was significantly higher in sepsis group than that in non-sepsis group (P<0.05). BMP-2 was found to be a marker for differential diagnosis of separating sepsis LPS may significantly increase the expression of BMP-2 of RPMECs but decrease the expression of phosphorylated Smad1/5 (pSmad1/5) and BMP receptor Ⅱ (BMPRⅡ) (P<0.05). Conclusions BMP-2 is a potential diagnostic marker and act as apro-inflammatory factor in early phase of sepsis.

Key words: sepsis, BMP-2, BMP/pSmad, pulmonary microvascular endothelial cells

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