Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (12): 1935-1938.doi: 10.16352/j.issn.1001-6325.2022.12.1935

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Research progress on STAT3 and pathogenesis of Parkinson's disease

WU Chang-bao1, HAO Yan-lei2*   

  1. 1. Medical College of Jining Medical University, Jining 272029;
    2. Department of Neurology, Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Received:2022-06-10 Revised:2022-09-28 Online:2022-12-05 Published:2022-11-23
  • Contact: *

Abstract: Parkinson's disease (PD) is a chronic progressive neurodegenerative disease. Signal transducer and activator of transcription 3 (STAT3) is involved in the development and progression of PD, oxidative stress, neuro-inflammatory response, abnormal α-synuclein aggregation, mitochondrial dysfunction and iron death, so they are expected to be a new therapeutic targets and provide new research ideas for the treatment of PD.

Key words: STAT3 transcription factor, Parkinson's disease, pathogenesis

CLC Number: