Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (1): 149-153.

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Research progress in colitis-induced hepatic barrier dysfunction


  • Received:2020-08-14 Revised:2021-01-07 Online:2022-01-05 Published:2022-01-05
  • Contact: Hongyan Qin

Abstract: Liver barrier, the main structure to protect the liver from exogenous harmful substances, plays an important role in maintaining secretion function, regulating bile transport and intercellular information transmission. Liver barrier protein alteration and barrier dysfunction can be induced by endotoxin, inflammatory cytokines and bile acids, which may be involved in the occurrence of colitis-related liver diseases. To explore the effect and underlying mechanism of intestinal inflammation on liver barrier function may explain the pathogenesis of colitis-related liver diseases, and thus provide clues and basic information for its prevention and treatment.

Key words: colitis, liver barrier, endotoxin, bile acids, inflammatory cytokines