Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (9): 1360-1365.

• Mini Reviews • Previous Articles     Next Articles

Research progress of clinical effects of anti-Ro52/TRIM21 antibody in connective tissue diseases

YAN Ting-ting1,2, XUE Jing1*   

  1. 1. Department of Rheumatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000;
    2. Department of Rheumatology, the Second Affiliated Hospital of Jiaxing,Jiaxing 314000, China
  • Received:2020-04-15 Revised:2020-10-15 Online:2021-09-05 Published:2021-09-02
  • Contact: *jingxue@zju.edu.cn

Abstract: Anti-Ro52 autoantibody, also known as anti-TRIM21 autoantibody, is one of the widespread autoantibodies in connective tissue diseases(CTD). It was first detected in the patients of Sjögren's syndrome(SS), which had long been considered as an unknown component of anti-SS/Ro autoantibodies. With the development of molecular biology technology, antibodies against Ro52 are considered as independent auto-antibodies. However, there is still some uncertainty about the clinical applications. Recent studies have found that various connective tissue diseases can be positive for anti-Ro52 antibodies alone or in combination with other ones, leading to clinical manifestations or prognosis heterogeneity.

Key words: anti-Ro52 autoantibody, anti-TRIM21 autoantibody, connective tissue disease, interstitial lung disease

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