Abstract: Objective To explore the clinical characteristics and treatment outcome of testicular cancer. Methods To review retrospectly the clinical data of 49 patients who were diagnosed with testicular cancer and treated with operation in the Urology Department of Peking University Cancer Hospital. Results Among the 49 patients, 11 had elevated preoperative alpha fetal protein(AFP) levels, all have the age as≤ 44 years; 21 had elevated β-human chorionic gonadotropin(β-hCG) level, including 19 cases with age as ≤ 44 years; 20 had elevated lactate dehydrogenase(LDH), including 18 cases with the age as ≤ 44 years. Two weeks after operation, there were 2 cases of abnormal AFP, both ≤ 44 years old; 6 cases of abnormal β-hCG, including 5 cases ≤ 44 years old; LDH were all normal. All patients underwent radical resection of testicular cancer, including 6 patients with retroperitoneal lymph node dissection(RLND), and 23 patients with postoperative radiotherapy/chemotherapy followed. Conclusions The significance of AFP, β-hCG and LDH is greater for the diagnosis and evaluation of patients < 45 years old. Markers with higher sensitivity and specificity are needed for evaluation. RLND can be an option for initial treatment.

Key words: testicular cancer, tumor biomarkers, radical testicular cancer