Research progress on post-transcriptional dysregulation of mRNA in pathogenesis of Alzheimer's disease

Abstract

Abstract: Post-transcriptional regulation of mRNA is an essential step from RNA transcription to gene translation, the process includes mRNA splicing, nuclear export, translation, and decay. Post-transcriptional dysregulation in the brain is one of the causal factors of Alzheimer's disease. This review summarizes the dysfunctional post-transcriptional regulation of APP, MAPT and many other risk genes of AD identified so far. Meanwhile, RNA N⁶-methyladenosine methylation is the most abundant epitranscriptomic mark on mRNA and regulate almost every step in mRNA metabolism. Due to the abnormal expression of m⁶A regulators and participation in alternative splicing of risk genes in AD, the hypothesis proposes that post-transcriptional dys-regulation mediated by m⁶A may function as a novel pathogenic factor of AD .

Key words: Alzheimer's disease, mRNA, post-transcriptional regulation, RNA m⁶A methylation

CLC Number:

R741.02

SUN Jing-yao, TONG Wei-min, NIU Ya-mei. Research progress on post-transcriptional dysregulation of mRNA in pathogenesis of Alzheimer's disease[J]. Basic & Clinical Medicine, 2021, 41(5): 749-752.

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