Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (5): 749-752.

• Mini Reviews • Previous Articles     Next Articles

Research progress on post-transcriptional dysregulation of mRNA in pathogenesis of Alzheimer's disease

SUN Jing-yao, TONG Wei-min, NIU Ya-mei*   

  1. Department of Pathology, Institute of Basic Medical Sciences CAMS,School of Basic Medicine PUMC, Beijing 100005, China
  • Received:2020-05-09 Revised:2020-08-24 Online:2021-05-05 Published:2021-05-06
  • Contact: *niuym@ibms.pumc.edu.cn

Abstract: Post-transcriptional regulation of mRNA is an essential step from RNA transcription to gene translation, the process includes mRNA splicing, nuclear export, translation, and decay. Post-transcriptional dysregulation in the brain is one of the causal factors of Alzheimer's disease. This review summarizes the dysfunctional post-transcriptional regulation of APP, MAPT and many other risk genes of AD identified so far. Meanwhile, RNA N6-methyladenosine methylation is the most abundant epitranscriptomic mark on mRNA and regulate almost every step in mRNA metabolism. Due to the abnormal expression of m6A regulators and participation in alternative splicing of risk genes in AD, the hypothesis proposes that post-transcriptional dys-regulation mediated by m6A may function as a novel pathogenic factor of AD .

Key words: Alzheimer's disease, mRNA, post-transcriptional regulation, RNA m6A methylation

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