Basic & Clinical Medicine ›› 2021, Vol. 41 ›› Issue (2): 155-158.

• Original Articles •     Next Articles

The anti-Candida albicans infection of mouse by extracellular polysaccharide from PH1008

WANG Ying1, BEI Ning3, PEI Hua2*, YANG Wen1, WANG Hua-min1   

  1. 1. Laboratory of Pathogenic Biology and Immunology, Hainan Medical University, Haikou 571199;
    2. Department of Laboratory, the Second Affiliated Hospital,Hainan Medical University,Haikou 570000;
    3. the Fourth Department of Hainan Geriatric Hospital,Haikou 571100,China
  • Received:2020-01-09 Revised:2020-05-25 Online:2021-02-05 Published:2021-01-19
  • Contact: *

Abstract: Objective To evaluate the anti-infective effect of polysaccharide isolated from fungus PH1008 in vaginal Candida albicans infection model of mouse,and to provide a new and potential pathway to the development of anti-candida drugs. Methods Determination of gene expression level of transcriptome in mice vagina after yeast infection mouse model was treated by exopolysaccharide of fungus PH1008. Results The expression of hepatocyte growth factor and complement 1 receptor was increased, and the up-regulation was related to varied signal transduction pathways. Conclusions The anti-infection effect of Candida albicans can be induced by vaginal mucosal immunization with exopolysaccharide of fungus PH1008, and the relevant mechanism needs further research.

Key words: mangrove fungus, infection, vagina

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