Research advance of myokines on bone metabolism regulation

Abstract

Abstract: Bone and muscle are closely interrelated.Muscle can synthesize and secrete a series of myokines,which play important roles on the growth,development and function of the bone.Myokines can regulate the function of osteoblasts,osteoclasts and osteocytes,which can be divided into factors that promote bone anabolism,increase bone catabolism or regulate bone turnover in a double-edged way.This article reviews the advance of myokines which have important regulatory effects on bone metabolism,to reveal the regulatory network between muscle and bone,and provide new targets for the treatment of musculoskeletal diseases.

Key words: myokines, muscle, bone, bone metabolism

CLC Number:

R337

ZHOU Bing-na, LI Mei. Research advance of myokines on bone metabolism regulation[J]. Basic & Clinical Medicine, 2021, 41(12): 1809-1812.

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