Clinical characteristics and therapeutic strategy of urogenital solitary fibrous tumors

Abstract

Abstract: Objective To analyze, summarize and explore the diagnostic methods and treatment strategies of urogenital solitary fibrous tumor (SFT). Methods The study was carried out by reporting a male patient with urogenital SFT, and by reviewing the demographic, clinical and pathological features, treatment and follow-up of 35 patients reported from 2008 to 2018. Results Of the 35 patients, 24 (68.6%) had urinary symptoms, while 11 (31.4%) had no obvious complaints of discomfort at the time of diagnosis. In terms of pathological results, the surgical and pathological specimens of 34 patients (97.1%) were CD34⁺, and 27 cases (77.1%) were Bcl-2⁺. Conclusions The MRI and CT are efficient technology for detection of the SFTs. The immunohistochemical test of surgical specimens is the key to establish diagnosis, especially the characteristic staining of CD34, Bcl-2,STAT6 and ALDH2 is of great value in the diagnosis. In addition, the detection of NAB2-STAT6 fusion protein by molecular pathology also facilitate the diagnosis of SFTs. Surgical resection is the best therapy for SFTs.

Key words: solitary fibrous tumor, urogenital system, mensenchymal tumor

CLC Number:

R737.1

ZHAO Zhao, LIU Fan, JI Zhi-gang, ZHANG Zhen-yu, HUANG Zhong-ming, SHI Bing-bing. Clinical characteristics and therapeutic strategy of urogenital solitary fibrous tumors[J]. Basic & Clinical Medicine, 2020, 40(7): 975-979.

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