Abstract: Objective To investigate the clinical efficacy of compound betamethasone combined with semiconductor laser in the treatment of erosive oral lichen planus (EOLP). Methods Ninety cases with erosive lesions and pathologically confirmed EOLP diagnosed in the Department of Oral Mucosa of Qingdao Municipal Hospital were selected and randomly divided into three groups A, B, and C, with 30 cases in each and treated respectivel for 28 days. Group A patients were treated with compound betamethasone under local anesthesia (2 weeks/time); group B patients were treated with semiconductor laser local irradiation (3 times/week); group C patients were treated with betamethasone combined with semiconductor laser treatment.The lesion area and local focus were observed and recorded after 2 weeks and 4 weeks, Saliva were collected before and after treatment to detect the levels of IL-17 and IL-38, C.albicans were isolated with routine technology. Results After treatment, the lesion area of group C was significantly smaller than that of group A and group B(P＜0.05); the pain degree scores of group C were significantly lower than those of groups A and B(P＜0.05); the local focus scores of group C were significantly lower than those of groups A and B(P＜0.05). After treatment, the detection rate of C.albicans in group A, B and C patients was statistically significant(P＜0.05). After treatment, IL-17 and IL-38 in group C were significantly different from those in groups A and B(P＜0.05). Conclusions The overall effect of therapy with betamethasone plus semiconductor laser in the treatment of EOLP is better than that either mono-thearpy.

Key words: erosive oral lichen planus, semiconductor laser, compound betamethasone, Candida albicans