Basic & Clinical Medicine ›› 2020, Vol. 40 ›› Issue (12): 1721-1726.

• Mini Reviews • Previous Articles     Next Articles

Research progress of different cells derived exosomes in COPD

YANG Yue, BIAN Tao*   

  1. Department of Respiratory and Critical Illness, Wuxi People's Hospital, Nanjing Medical University, Wuxi 214000, China
  • Received:2020-06-28 Revised:2020-08-26 Online:2020-12-05 Published:2020-11-30
  • Contact: * biantaophd@126.com

Abstract: Exosomes are lipid bilayer vesicles secreted by almost all types of cells, which consist of various proteins, DNA, mRNA, miRNA and LncRNA. They are an important medium for communication between cells and participate in various physiological and pathological processes. In chronic obstructive pulmonary disease (COPD), bronchial epithelial cells, macrophages, neutrophils and other cells can participate in COPD airway remodeling and emphysema by secreting exosomes. Moreover, mesenchymal stem cells and adipose stem cell-derived exosomes play an important role in the treatment of COPD.

Key words: exosomes, COPD, bronchial epithelial cell, macrophages, neutrophil

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