Research progress of fibroblast growth factor homologous factor 1 in the pathogenesis of arrhythmia

Abstract

Abstract: Fibroblast growth factor homologous factor 1 (FHF1) is an intracellular signaling protein, a non-specific fibroblast growth factor that does not bind to fibroblast growth factor receptors. FHF1 combines with the C-terminus of cardiac voltage-gated sodium ion channels to regulate Na⁺current, which in turn affects the action potential of myocardial cells and results in arrhythmias with a higher frequence.

Key words: fibroblast growth factor homologous factor, arrhythmia, sodium channel, phosphorylation

CLC Number:

R541.7

QIN Tao, LI Qing, LI Ju-xiang. Research progress of fibroblast growth factor homologous factor 1 in the pathogenesis of arrhythmia[J]. Basic & Clinical Medicine, 2020, 40(12): 1697-1700.

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