Basic & Clinical Medicine ›› 2020, Vol. 40 ›› Issue (11): 1551-1555.

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Research progress on the role of platelet-derived microparticles in the development of atherosclerosis

GUO Fang-jun, YANG Ren-qiang*   

  1. Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, China
  • Received:2020-04-08 Revised:2020-06-28 Online:2020-11-05 Published:2020-10-30
  • Contact: *

Abstract: Platelet-derived microparticles(PMPs) are extremely small vesicles with complex structure and composition released by platelets, which contain proteins, mRNAs, miRNAs and other bioactive substances and participate in various pathophysiological processes. PMPs promote the development of atherosclerosis(AS) by participating in the processes of vascular endothelial cell injury, inflammatory reaction, lipoprotein deposition, macrophage phagocytosis and plaque instability. Anti-platelet drugs can lower down the plasma level of PMPs. Therefore, PMPs provide a new perspective for the explanation of the pathogenesis and treatment of cardiovascular diseases.

Key words: platelet-derived microparticles, atherosclerosis, endothelial cells, inflammatory reaction

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