Basic & Clinical Medicine ›› 2020, Vol. 40 ›› Issue (11): 1542-1545.

• Mini Reviews • Previous Articles     Next Articles

Progress on the correlation between exosomal microRNAs and Alzheimer's disease

DIAO Hua-qiong1, LI Xiao-li2*, LIN Liang-yin1, LIU Hai-peng1, CHEN Hong-jing1, DING Hai-yue1, WEI Dan1   

  1. 1. Beijing University of Chinese Medicine, Beijing 100029;
    2. Department of Encephalopath, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2019-10-18 Revised:2020-01-03 Online:2020-11-05 Published:2020-10-30
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Abstract: Alzheimer's disease is the most common dementia in the aged population and is characterizd by hidden attack and progressive development. Some studies showed that exosomal microRNAs(miRNAs) regulates the shearing of amyloid precusor protein,deposition of beta-amyloid peptides(Aβ) and phosphorylation of Tau protein, influencing the generation of neuritic plaques and neurofibrillary tangles. In addition, special miRNAs can be transpor-ted by exsome across blood-brain-barrier and inhibit Tau phosphorylation. Measuring the expression profile of exosomal miRNAs in the peripheral blood may be a non-invasive diagnosis and treatment method of AD.

Key words: Alzheimer's disease, exosome, microRNAs, beta-amyloid peptide, Tau protein

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