Abstract: Exosomes are a type of extracellular vesicles secreted by cells, it is shapes like cup with a diameter of 30 to 140 nm. at present, exosomes show strong pontential in early diagnosis, drug target transport, tissue regeneration. In bone tissue engineering, exosomes can deliver special proteins, miRNAs, biofactors to stimulate MSCs differentiate into osteoblasts as well as up-regulating the expression of related osteogenic genes for repair bone defect and achieve bone regeneration.

Key words: Key: exosomes, bone tissue engineering, tissue regeneration, Osteogenic differentiation