Abstract: Angiotensin II, adrenocorticotrophic hormone and potassium are the main physiological stimulus that promote aldosterone secretion. All of the three kinds of stimulus could activate voltage-gated calcium channel in adrenal cortical cells. Calcium influx through voltage-gated calcium channel is the common path in the synthesis of aldosterone. Calcium concentration in ATP1A1, ATP2B3, CACNA1D and KCNJ5 mutated aldosterone producing adenomas are also elevated. Calcium signal will promote aldosterone secretion though Ca2+-CaM-CaMK pathway.

Key words: calcium signal, the secretion of aldosterone, aldosterone producing adenoma