Abstract: Objective To study the frequencies of allele and genotype distribution of Key enzyme of alcohol metabolism ALDH2 Gene G1510A polymorphisms in the Hui and Han people in Ningxia Province. Method The key enzyme of alcohol metabolism ALDH2 Gene G1510A polymorphisms was examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods in 162 hui and 236 han healthy adults. Results　The key enzyme of alcohol metabolism ALDH2 Gene G1510A genotypes and alleles frequencies were（GG：69.14%；GA：27.16%；AA：3.70%；G：82.72%；A：17.28%）of Ningxia Hui ethnic, respectively.The key enzyme of alcohol metabolism ALDH2 Gene G1510A genotypes and alleles frequencies were（GG：71.19%；GA：25.00%；AA：3.81%；G：83.69%；A：16.31%）of Ningxia Han ethnic. The Phenotype frequency and allele gene frequency of The key enzyme of alcohol metabolism ALDH2 Gene G1510A were not significantly different between the female and male people in Ningxia too. Conclusion The key enzyme of alcohol metabolism ALDH2 Gene G1510A distribution in the Hui and Han ethnic of Ningxia is not significantly different.

Key words: The key enzyme of alcohol metabolism, ALDH2 Gene, Gene polymorphism