Basic & Clinical Medicine ›› 2019, Vol. 39 ›› Issue (2): 187-191.

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Relationship between 69C/T gene variation and degree of coronary stenosis in patients with coronary heart disease

  

  • Received:2018-03-01 Revised:2018-05-31 Online:2019-02-05 Published:2019-01-16

Abstract: Objective To investigate whether ATP-binding cassette transporter 1(ABCA1) 69C/T single nucleotide polymorphisms variation is correlated with coronary heart disease(CHD) in the Inner Mongolia region,and the association of this polymorphism with blood lipids,degree of pathological changes in coronary artery . Methods The target fragments of ABCA1gene was amplified and analyzed by polymerase chain reaction(PCR)-restriction fragments length polymorphism(RFLP) technique in 345 patients with CHD and control subjects without CHD. Results 1. The frequency of TT genotype and T allele of ABCA1 69C/T gene was all significantly higher in CHD patients than that in controls(P<0.05). TT genotype odds ratio was 2.938(95%CI: 2.048~4.216,P <0.05).It was shown TT genotype were risk factors for CHD accidents by logistic analysis. 2. There was an obviously different distribution frequency of the TT genotype and T alleles of 69C/T gene in single、double and multi coronary artery lesion group(P<0.05),as well as that in A、B and C type group of coronary artery lesion(P<0.05). Conclusions ABCAl gene 69C/T polymorphism is associated with CHD risk in the Inner Mongolia region.The TT genotype and T alleles of the ABCA1 gene 69C/T polymorphism is associated with increased CHD risk. The TT genotype and T alleles of the ABCA1 gene 69C/T、-565C/T can increased the area and severity of coronary artery lesion.

Key words: coronary heart disease, ATP binding cassette transporter 1, coronary artery lesion

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