Abstract: Acute respiratory distress syndrome (ARDS) is a critical syndrome in respiratory department and intensive care department, with no effective treatment and the mortality rate of which is extremely high. Endoplasmic reticulum stress plays an important role in the onset and development of acute respiratory distress syndrome (ARDS) by inducing inflammation and cell apoptosis, while inhibition of endoplasmic reticulum stress could alleviate ARDS.

Key words: endoplasmic reticulum stress, acute respiratory distress syndrome, pathogenesis, therapy