Abstract: Objective: To investigate the effect of angiotensin receptor blocker valsartan combined with amlodipine in the treatment of hypertensive nephropathy. Methods: Totally 84 patients admitted to the Second Affiliated Hospital of Nantong University from January 2015 to June 2018 were included in this study. They were randomly divided into observation group and control group, 42 cases each. The control group was treated with valsartan only, while the observation group was treated with valsartan and amlodipine. The changes of blood pressure and renal function indexes were observed after treatment. Results: The levels of SBP, DBP, urea nitrogen (BUN), creatinine (Scr) and 24h urinary protein in the observation group were lower than those before intervention (P < 0.05), while the levels of SBP, DBP, BUN, Scr and 24h urinary protein in the control group were lower than those before intervention (P<0.05). Compared with the control group, BUN, Scr and 24h urine protein levels were lower than those of the control group (P<0.05). Conclusions: Valsartan can control blood pressure and protect renal function in the treatment of hypertension nephropathy. Valsartan combined with amlodipine has better therapeutic effect than valsartan alone.

Key words: Valsartan, Amlodipine, Hypertensive Nephropathy