Abstract: Objective To observe the clinical effect and safety of buprenorphine transdermal patch for analgesia after thoracoscopic surgery. Methods 100 patients with stage I lung cancer undergoing thoracoscopic surgery were randomly divided into observation group (51 cases) and control group (49 cases). The observation group was treated with buprenorphine transdermal patch for postoperative analgesia, while the control group was treated with oxycodone paracetamol for postoperative analgesia. Both groups were treated with parecoxib sodium for combined analgesia. The postoperative pain, satisfaction with analgesia and the occurrence of adverse reactions were observed in both groups. Results Within 3 days after operation, the degree of resting pain and motor pain in observation group was lower than that in control group (P < 0.001), the amount of morphine converted in observation group was much lower than that in control group (P< 0.001), and the satisfaction of patients in observation group was higher than that in control group (P < 0.001). The overall incidence of adverse reactions in the control group was higher than that in the observation group (P< 0.001). Conclusions Buprenorphine transdermal patch has good analgesic effect after thoracoscopic surgery and can reduce the amount of opioids used in perioperative period.

Key words: Key words: Buprenorphine transdermal patch, Postoperative analgesia, Thoracoscopic surgery