Abstract: Parkinson's disease is a neurodegenerative disease, whose cause and the mechanism is unclear. We gradually discover that genes related to PD,such as SNCA, GBA, LRRK2, SCARB2, LAMP3, BAB29/RAB7L1, MAPT, GAK, SREBF1, GPNMB, et al., increase the indicine of the sporadic PD. SNCA gene and GBA gene are the genetic factors of PD, and their interaction in PD is still illuminated.

Key words: PD, SNCA, GBA, SNCAgene, GBA gene