Abstract: Objective To explore the effect of the combination of CPT1 inhibitor etomoxir and chemotherapy drug-- cisplatin on A549 cells proliferation and migration of lung cancer. Methods CCK8 was applied to investigate the effects of the combination of etomoxir and cisplatin on A549 survival. Transwell test was used to detect migration of lung cancer cell line A549 cells treated with the combination of etomoxir and cisplatin. Apoptosis of lung cancer cells was detected by annexin V/PI. A549 cells transplanted mice were used to test therapeutic effect of etomoxir combined with cisplatin. Results Tumor cells proliferation and migration wasinhibited by the com-bination of etomoxir and cisplatin. And apoptosis of tumor cells was enhanced by the combination of etomoxir and cisplatin can inhibit. After the treatment of the combination of etomoxir and cisplatin, tumor growth of mouse was inhibited. Conclusions The combination of etomoxir and cisplatin can decrease tumor cells survival and induce tumor cells apoptosis, and then inhibit tumor growth in mouse lung cancer model.

Key words: Cisplatin, Etomoxir, lung cancer, tumor therapy, CPT1