Abstract: Objective To investigate the effect of microecological therapy on rotavirus (RV) diarrhea in infants and influence of it on the infants’ immunologic function. Methods 150 infants with RV diarrhea were randomly divided into the experimental group and the control group, each with 75 cases. The control group was given the treatment of montmorillonite powder. While the experimental group was given live combined bifidobacterium and lactobacillus tablets based on the application of montmorillonite powder. The clinical efficacy and the improvement of clinical symptoms were compared between the two groups. To detected RV antigen and immunologic function with colloidal gold method. Immune function was detected by flow cytometry and ELISA.Results The total effective rate of the experimental group were 74.7%,and it was significantly higher than that of the control group which was 90.7% (P<0.05). Compared with the control group, the antidiarrheal time, fever clearance time and disappearance time of vomiting symptoms in the experimental group were shorter (P<0.05). The negative conversion rate of RV virus antigen in the experimental group after 1 and 2 weeks treatment were significantly higher than that in the control group (P < 0.05). After 3 weeks treatment, RV virus antigen in the experimental group all turned negative, but the control group still had a positive rate of 12.0% (P<0.05). The peripheral blood CD3+, CD4+ and the ratio of CD4+/CD8+ in the experimental group after treatment were significantly higher than those before treatment and those in the control group after treatment (P<0.05), as well as the levels of serum immunoglobulin A (IgA) and IgM (P<0.05). No adverse reactions occurred during the treatment period in the two groups. Conclusions Microecological therapy has an exact curative effect and high security in the treatment of infantile RV diarrhea. And it could effectively improve the immunologic function of the infants.

Key words: Key words: Rotavirus, Diarrhea, Microecological therapy, Immunologic function, Infants