Abstract: Objective To study the advantages and disadvantages of two different methods（the peripherally inserted central venous catheter (PICC) and the totally implantable venous-access ports (TIVAP) in the chemotherapy of tumor patients. Methods The clinical data of 160 patients treated with PICC or TIVAP from March 2016 to December 2016 were retrospectively analyzed, and the complications of the two groups were compared and analyzed. Results The catheter occlusion rate, catheter infection rate and the incidence of phlebitis in the TIVAP group were lower than that in the PICC group (P<0.05). Conclusion The patents treated with TIVAP have fewer complications. The indwelling time is prolonged, and the quality of life of patients with the tube has no significant difference.