Abstract: Objective To investigate the relation between expression of JARID1B/KDM5B in invasive breast cancer tissue and circulating tumor cells of invasive breast patients. Methods The S-P immunohistochemical method was used to observe the expression of JARID1B/KDM5B in lesions. ImFish method was used to detect circulation tumor cells. Results Twenty-seven cases of patients showed CTC positive (the number of CTC was more than or equal to 2) in 35 invasive breast cancer cases,The results of JARID1B/KDM5B expression were as follows: (-) (n = 0) and (+) in 1 case, (+ +) in 3 cases, (+ + +) in 23 cases, 8 cases of negative cases (the number of CTC < 2),JARID1B/KDM5B immune group of results: (-) (n=2), (+) in 2 cases, (+ +) in 1 case, (+++) in 3 cases，The positive relation was found in expression of JARID1B/KDM5B and circulating tumor cells（P<0.05）. Conclusions JARID1B/KDM5B positive expression in tumor tissues has a certain significance in judging the recurrence and metastasis of tumor.

Key words: JARID1B,Invasive breast cancer ,imFISH.