Abstract: Colon cancer associated transcript 1 (CCAT1) is a kind of long non-coding RNA (lncRNA) found recently, which is aberrant overexpression in colorectal cancer, and it can promote cancer cell proliferation, invasion and metastasis. CCAT1 involves in the regulation of multiple pathophysiological processes, especially the formation and progression of gastrointestinal cancer, through the interaction with microRNA (miRNA) or protein by regulation mechanism like endogenous competition, and it is expected to serve as a valuable biomarker and therapeutic target.

Key words: LncRNA, CCAT1, gastrointestinal cancer