Abstract: Previous studies have shown that excessive accumulation of reactive oxygen species(ROS) and chronic avtivation of mTORC1 will result in aging.Sestrins,a family of highly consevered stress-inducible proteins,are important negative regulators of both ROS and mTORC1 signaling pathways;however,the mechanistic basis of how sestrins suppress these pathways remains unknown.In recent years,great disvoveries about sestrins have deeply increased our understanding of sestrin function.These disvoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-related diseases.

Key words: Key words：sestrins, oxidative stress , target of rapamycin, aging