Abstract: Interleukin 25 (IL-25) is a member of the IL-17 family and plays an important role in chronic inflammation and cancer. IL-25 can activate hepatic stellate cells and induce the expression of downstream cytokines IL-4 and IL-13, which promote liver fibrosis; IL-25 can promote M2 Macrophages polarization and maybe can recruit LY-6Clo infiltrating macrophages, which inhibit liver fibrosis, Therefore, the relationship between IL-25 and its related factors with liver fibrosis is yet unclear.

Key words: Interleukin 25, Macrophages, Liver fibrosis