Abstract: The glympahtic system rapidly removes metabolic waste in the brain through the drainage and material exchange between cerebrospinal fluid and interstitial fluid. The influencing factors include AQP-4, cerebral artery pulse, sleep and body posture. Glympahtic system dysfunction can lead to a variety of diseases related to cognitive impairment. Glymphatic system function recovery may be a new way to prevent and treat diseases related to cognitive impairment.

Key words: glymphatic system, paravascular space, cognitive impairment