Abstract: Renal impairment is common in multiple myeloma. Besides effective chemotherapy, direct removal of serum free light chain through plasmapheresis or high cut-off hemodialysis is also important in the treatment of renal impairment in multiple myeloma. Based on results of the randomized controlled trials, the role of plasmapheresis in treating renal disease of multiple myeloma is debated. On the other side, high cut-off hemodialysis is novel and recently developed. Many studies have observed its ability to further increase renal response rate when combined with chemotherapy.

Key words: plasmapheresis, high cut-off hemodialysis, renal impairment of multiple myeloma, cast nephropathy, serum free light chain