Abstract: Objective To investigate the clinicopathological characteristics, diagnosis and treatment of huge adrenal tumor. Methods Retrospectively analysed the clinical data of the 2 patients with huge adrenal tumor more than 10 cm in diameter, who were admitted in our hospital from September 2013 to January 2015. Clinical manifestations, treatment methods and prognosis were analyzed. Results Two patients were both suspected of adrenocortical carcinomas. Case 1 was a 28-year-old female. Laparoscopic surgery was performed at first but was conversed to open palliative adrenalectomy due to tumor rupture and bleeding. The postoperative pathology was adrenocortical carcinoma. The patient died of gastrointestinal bleeding caused by tumor metastasis 10 months later. Case 2 was a 39-year-old female, who underwent laparoscopic adrenolectomy with tumor excision completely. The postoperative pathology showed neoplasm of malignant potential, and no tumor recurred during 15 months follow-up. Conclusions Open surgery should be priority if the diameter of adrenal tumor is more than 10 cm and diagnosis as suspicious of malignancy.huge adrenocortical carcinoma shows poor therapeutic effects,and multimodality therapy may improve the prognosis.

Key words: adrenal tumor, huge, adrenocortical carcinoma