Abstract: Perioperative pain management play a critical role in rapid recovery and long term outcome in patient undergoing total knee arthroplasty. With the advancement of peripheral nerve block, technique such as femoral nerve block, sciatic nerve block, abductor canal blockhave play an important role in perioperative pain management. Local infiltration analgesia have also gained popularity. The ultimate goal of perioperative pain management is to ensure analgesia effect and maintain good motor function of lower extremity. We are still in searching of a safe, effective, analgesia without motor block. Currently multimodal analgesia seems to be the most favorable choice.