Abstract: Objectives: To investigate the clinical characteristics and treatments of endometrioid carcinoma patients with preoperative diagnosis of endometrial hyperplasia. Methods: Between 2005 and 2010, 404 patients were diagnosed with endometrioid carcinoma after hysterectomy. Among these patients,44 of them were diagnosed atypical endometrial hyperplasia (AEH) preoperatively. Retrospectively analysis the characteristics of these patients with Spss13.0. Results: Among the 44 cases, all of them were grade G1 disease, and 39 of them received comprehensive staging surgery. 14 （32%）young cases preserved bilateral ovaries. 9 cases (20%) were given adjuvant radiology. No recurrence was detected during the median follow up of 52 months. Compared to the premenstrual group, although no statistical difference was detected, more patients with risk factors of deep myometrium invasion (4/22 vs 1/22) and lymph-vascular space invasion(LVSI, 3/22 vs 0/22) in the postmenstrual group. Compared to the patients who diagnosed with endometrioid cancer (EC) preoperatively, there are more patients with grade G1 (P=0.000)) , fewer patients received adjuvant chemotherapy (p=0.03) and fewer recurrence (p=0.019) in AEH group. Conclusion: The endomtrioid cancer patients who diagnosed with atypical hyperplasia preoperatively have better prognosis. Hysterectomy with bilateral ovaries preserved is acceptable in young patients. Post menopause patients with have more risk factors of deep myometrium invasion and LVSI.

Key words: endometrial hyperplasia, endometrioid carcinoma