Basic & Clinical Medicine ›› 2017, Vol. 37 ›› Issue (11): 1629-1633.

Previous Articles     Next Articles

Research progress of sodium-dependent phosphate transporter in gout / hyperuricemia


  • Received:2017-03-30 Revised:2017-06-26 Online:2017-11-05 Published:2017-11-01

Abstract: Sodium-dependent phosphate cotransporter is encoded by the solute carrier family 17 gene. The gene is located on chromosome 6 and is an important transporter of the organic anion as the substrate and is expressed in kidney and other tissues.Among them, the sodium-dependent phosphate transporter type 1, 3, and 4 have the function of transferring uric acid, and abnormal function can lead to the decrease of uric acid excretion, which can cause hyperuricemia and even induce gout.

Key words: uric acid, hyperuricemia, gout, sodium-dependent phosphate cotransporter, genetic polymorphism

CLC Number: