Abstract: CyclophilinD(CypD) , a member of the cyclophilins family, displays a variety of biological function. CypD locates in the mitochondrial matrix. As an component of mitochondrial permeability transition pore (mPTP), CypD plays an important role in the regulating of mPTP opening, which leads to mitochondrial dysfunction and CypD-dependent regulated necrosis. Elucidation of the mechanisms of CypD in regulating mPTP and the regulated necrosis will provide novel insights in injury-relevant diseases, such as cardiac or cerebral ischemia.

Key words: cyclophilin D, mPTP, regulated necrosis, cyclosporine A