Abstract: Objective To investigate the effect of tamibarotene（Am80）on cerebral ischemia reperfusion injury．Methods Rats were randomly divided into sham operation group (Sham), model group (I/R) and tamibarotene intervention group (Am80, intragastric administration of Am80 6mg/kg). The middle cerebral artery occlusion (MCAO) was established by using suture method. At 24 h after reperfusion, the brain was removed. And the neurological behavioral score was assessed by double blind method. The cerebral infarction volume was measured by TTC staining. The proteins of RARα, Bcl-2, Bax and mRNA were examined by Western blot and RT-qPCR, respectively. Results Am80 significantly improved the neurological deficits of MCAO rats and effectively reduced the infarct volume. And upregulated the level of RARα and Bcl-2, decreased the expression of Bax. Conclusions Am80 has a protective effect on cerebral ischemia-reperfusion in rats, and its effect may be related to anti-apoptosis.

Key words: Key words：tamibarotene, cerebral ischemia-reperfusion injury, apoptosis.